HOW AND WHERE TO BUY MODAFINIL (PROVIGIL, ALERTEC, MODALERT, MODVIGIL) 100 MG, 200 MG TABLETS OR CAPSULES ONLINE:
from $0.82 per pill
10% discount coupon: hf-5478
from $1.00 per Modafinil pill
from $1.20 per Modalert pill
from $1.80 per Modvigil pill
GENERIC DRUGS SHOP
from $1.24 per pill
10% discount coupon: qRr3ZyvhPv
MEDS ONLINE 365
from $2.22 per Modafinil pill
from $2.38 per Modalert pill
from $2.44 per Modvigil pill
PROVIGIL (MODAFINIL): SPECIAL PRECAUTIONS
Patients should be advised to inform their physician if they are taking, or plan to take, any prescription or over-the-counter drugs, because of the potential for interactions between Provigil (Modafinil) and other drugs.
Patients should be advised that the use of Modafinil (Provigil) in combination with alcohol has not been studied. Patients should be advised that it is prudent to avoid alcohol while taking this medication.
Patients should be advised to stop taking Provigil (Modafinil) tablets and to notify their physician if they develop a rash, hives, mouth sores, blisters, peeling skin, trouble swallowing or breathing or a related allergic phenomenon.
Patients should be advised to notify their physician if they become pregnant or intend to become pregnant during therapy. Patients should be cautioned regarding the potential increased risk of pregnancy when using steroidal contraceptives (including depot or implantable contraceptives) with Provigil and for one month after discontinuation of therapy.
Patients should be advised to notify their physician if they are breast feeding an infant.
Carcinogenesis, Mutagenesis, Impairment of Fertility
Carcinogenicity studies were conducted in which modafinil was administered in the diet to mice for 78 weeks and to rats for 104 weeks at doses of 6, 30, and 60 mg/kg/day. The highest dose studied is 1.5 (mouse) or 3 (rat) times greater than the recommended adult human daily dose of modafinil (200 mg) on a mg/m2 basis. There was no evidence of tumorigenesis associated with modafinil administration in these studies. However, since the mouse study used an inadequate high dose that was not representative of a maximum tolerated dose, a subsequent carcinogenicity study was conducted in the Tg.AC transgenic mouse. Doses evaluated in the Tg.AC assay were 125, 250, and 500 mg/kg/day, administered dermally. There was no evidence of tumorigenicity associated with modafinil administration; however, this dermal model may not adequately assess the carcinogenic potential of an orally administered drug.
Modafinil (Provigil) demonstrated no evidence of mutagenic or clastogenic potential in a series of in vitro (i.e., bacterial reverse mutation assay, mouse lymphoma tk assay, chromosomal aberration assay in human lymphocytes, cell transformation assay in BALB/3T3 mouse embryo cells) assays in the absence or presence of metabolic activation, or in vivo (mouse bone marrow micronucleus) assays. Modafinil was also negative in the unscheduled DNA synthesis assay in rat hepatocytes.
Impairment of Fertility
Oral administration of modafinil (doses of up to 480 mg/kg/day) to male and female rats prior to and throughout mating, and continuing in females through day 7 of gestation produced an increase in the time to mate at the highest dose; no effects were observed on other fertility or reproductive parameters. The no-effect dose of 240 mg/kg/day was associated with a plasma modafinil exposure (AUC) approximately equal to that in humans at the recommended dose of 200 mg.
Buy Provigil (Modafinil) Online
Provigil prescribing information
Copyright © Buy Modafinil Online