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PROVIGIL (MODAFINIL): DOSAGE AND ADMINISTRATION

The recommended dose of Provigil (Modafinil) tablets is 200 mg given once a day.

For patients with narcolepsy and OSA, Modafinil (Provigil) should be taken as a single dose in the morning.

For patients with SWD, Provigil should be taken approximately 1 hour prior to the start of their work shift.

Doses up to 400 mg/day, given as a single dose, have been well tolerated, but there is no consistent evidence that this dose confers additional benefit beyond that of the 200 mg dose.

General Considerations

Dosage adjustment should be considered for concomitant medications that are substrates for CYP3A4, such as triazolam and cyclosporine.

Drugs that are largely eliminated via CYP2C19 metabolism, such as diazepam, propranolol, phenytoin (also via CYP2C9) or S-mephenytoin may have prolonged elimination upon coadministration with Provigil (Modafinil) and may require dosage reduction and monitoring for toxicity.

In patients with severe hepatic impairment, the dose of Modafinil (Provigil) should be reduced to one-half of that recommended for patients with normal hepatic function.

There is inadequate information to determine safety and efficacy of dosing in patients with severe renal impairment.

In elderly patients, elimination of Provigil (Modafinil) tablets and its metabolites may be reduced as a consequence of aging. Therefore, consideration should be given to the use of lower doses in this population.

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